4.3. Cellular Kinetics (Creatine Transporter)

The Creatine Transporter is a sodium/chloride-dependent transporter; dependent on both sodium[137][138] and chloride[139][140]. It belongs to the Na+/Cl-dependent family of neurotransmitter transporters.[141] On the muscle cells and most other cells,[129][139] the isomer of the creatine transporter is known as SLC6A8 and since it is a sodium-dependent transporter, it is involved with sodium flux across the membrane.[142] This isomer is coded by the gene present on Xq28 of the human chromosome and applies to most tissues[143], while the other gene capable of encoding for the Creatine Transporter, 16p11.1, creates transporters that are testicle exclusive.[144] These two transporters share 98% homology.[143][144]

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