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4.3. Cellular Kinetics (Creatine Transporter)
The Creatine Transporter is a sodium/chloride-dependent transporter; dependent on both sodium
[137][138] and chloride
[139][140]. It belongs to the Na+/Cl-dependent family of neurotransmitter transporters.
[141] On the muscle cells and most other cells,
[129][139] the isomer of the creatine transporter is known as SLC6A8 and since it is a sodium-dependent transporter, it is involved with sodium flux across the membrane.
[142] This isomer is coded by the gene present on Xq28 of the human chromosome and applies to most tissues
[143], while the other gene capable of encoding for the Creatine Transporter, 16p11.1, creates transporters that are testicle exclusive.
[144] These two transporters share 98% homology.
[143][144]
Creatine - Scientific Review on Usage, Dosage, Side Effects | Examine.com
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