ed ecco arrivare il piccolo chimico di fiducia...ahah...per velocizzarti la risposta che cerchi ho estratto la frase che ci interessa:
PI3K is inhibited by wortmannin, a fungal metabolite, which is an inhibitor of the lipid and protein kinase activities of the heterodimeric enzyme. The inhibition is irreversible and occurs by reacting covalently with lysine-802. The lysine residue is present in the p110a catalytic subunit. Lysine is a residue that is required for catalytic activity and this residue is conserved in all PI3K’s. ATP and ATP analogs effectively compete with wortmannin. Wortmannin is very potent and has been used to demonstrate the role of PI3K in diverse signal transduction processes. Another inhibitor is Ly294002 it reversibly inhibits PI3K.
se vuoi leggerti tutto l'articolo accomodati http://wwwchem.csustan.edu/chem4400/SJBR/angel99.htm
spero di esserti stato utile io e la mia insonia
ps.il primo inibitore lo trovi qui http://en.wikipedia.org/wiki/Wortmannin
il secondo è questo http://www.cellsignal.com/products/9901.html e qui puoi anche comprarlo http://www.caymanchem.com/app/templa...alog/70920/a/z
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