Integratori e Studi sulla Miostatina

[vincent.simeone]

Buongiorno, lo so ke è un argomento che è stato trattato un sacco di volte, però Bio-Hazard aveva chiesto una cosa a riguardo e traggo l'occasione

Allora esiste questo tipo di integratore sul mercato Cytodyne Myo-Blast CSP3 che però non è vendibile in ITALIA
il suo composto è :MyoZap™CSP3 (Cystoseira Canariensis), Rhodiola Rosea Extract(Standardized For 5% Rosavin), Rhaponticum Carthomides Extract(Standardized For 25% 20-Hydroxyecdysone), Anabolic Amino Acid Complex (Taurine, Carnosine, L-Leucine).
Tuttavia però questo integratore si è rilevato soltanto uno spreco di denaro.

Esistono poi dei veri e propri farmaci che in america chiamano waste of money che sono la Follistatina e il Peptide D76A (premetto però che non ne conosco e non sono esperto in materia quindi non so neanche come agiscono).La miostatina e' utilissima per combattere la distrofia muscolare però ha anche molti sides negativi.

Poi ci sono anche alcuni studi a riguardo: 1PRO e 2CONTRO :
studi pro:
Sulfated polysaccharides of brown seaweed Cystoseira canariensis bind to serum myostatin protein.

Ramazanov Z, Jimenez del Rio M, Ziegenfuss T.
The Technological Institute, Las Palmas, Spain.
Natural sulfated polysaccharides (SPs) derived from brown seaweed comprise a complex group of macromolecules with a wide range of important physiological properties. SPs have been shown to bind and directly regulate the bioactivity of growth factors and cytokines such as basic fibroblast growth factor, interferon, various enzymes and transforming growth factor. Myostatin is a member of the transforming growth factor-beta (TGF-beta) family that acts as a negative regulator of skeletal muscle mass. In this work we demonstrated that SPs isolated from the brown seaweed Cystoseira canariensis bind to the myostatin protein in serum.
PMID: 14570155 [PubMed - indexed for MEDLINE]



studi contro:
Effects of an alleged myostatin-binding supplement and heavy resistance training on serum myostatin, muscle strength and mass, and body composition.

Willoughby DS.
Exercise and Biochemical Nutrition Laboratory, Dept of Health, Human Performance, and Recreation, Baylor University, Waco, TX 76798-7313, USA.
This study examined 12 wk of resistance training and cystoseira canariensis supplementation on serum levels of myostatin and follistatin-like related gene (FLRG) and muscle strength and body composition. Twenty-two untrained males were randomly assigned to a placebo (PLC) or myostatin binder (MYO) group in a double-blind fashion. Blood was obtained before and after 6 and 12 wk of training. PLC and MYO trained thrice weekly using 3 sets of 6 to 8 repetitions at 85 % to 90 % 1 repetition maximum. MYO ingested 1200 mg/d of cystoseira canariensis. Data were analyzed with 2-way ANOVA. After training, total body mass, fat-free mass, muscle strength, thigh volume/mass, and serum myostatin and FLRG increased for both groups (P < 0.05); however, there were no differences between groups (P > 0.05). Twelve wk of heavy resistance training and 1200 mg/d of cystoseira canariensis supplementation appears ineffective at inhibiting serum myostatin and increasing muscle strength and mass or decreasing fat mass.
PMID: 15467103 [PubMed - indexed for MEDLINE]


IJSNEM, 14(4), August 2004, Copyright © 2004

Effects of an Alleged Myostatin-Binding Supplement and Heavy Resistance Training on Serum Myostatin, Muscle Strength and Mass, and Body Composition

Darryn S. Willoughby
Full Article Table of Contents for Vol. 14, Iss. 4

Abstract
This study examined 12 wk of resistance training and cystoseira canariensis supplementation on serum levels of myostatin and follistatin-like related gene (FLRG) and muscle strength and body composition. Twenty-two untrained males were randomly assigned to a placebo (PLC) or myostatin binder (MYO) group in a double-blind fashion. Blood was obtained before and after 6 and 12 wk of training. PLC and MYO trained thrice weekly using 3 sets of 6 to 8 repetitions at 85% to 90% 1 repetition maximum. MYO ingested 1200 mg/d of cystoseira canariensis. Data were analyzed with 2-way ANOVA. After training, total body mass, fat-free mass, muscle strength, thigh volume/mass, and serum myostatin and FLRG increased for both groups (P < 0.05); however, there were no differences between groups (P > 0.05). Twelve wk of heavy resistance training and 1200 mg/d of cystoseira canariensis supplementation appears ineffective at inhibiting serum myostatin and increasing muscle strength and mass or decreasing fat mass